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HelpMayo Test ID 11INT Factor XI Inhibitor Profile, Technical Interpretation
Specimen Required
Only orderable as part of a profile. For more information see 11INE / Factor XI Inhibitor Evaluation, Plasma
Useful For
Technical interpretation of inhibitor to coagulation factor XI testing
This test is not useful for the detection of a lupus-like circulating anticoagulant inhibitor, a nonspecific circulating anticoagulant, or other inhibitors that are not specific for coagulation factors.
Method Name
Only orderable as part of a profile. For more information see 11INE / Factor XI Inhibitor Evaluation, Plasma
Technical Interpretation
Reporting Name
FXI Inhib Profile Tech InterpSpecimen Type
Plasma Na CitSpecimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Plasma Na Cit | Frozen | 14 days |
Reject Due To
| Gross hemolysis | Reject |
| Gross lipemia | Reject |
| Gross icterus | Reject |
Clinical Information
Factor XI inhibitors typically arise in patients with congenital XI deficiency (hemophilia C) or after infusion of fresh frozen plasma or factor XI concentrates. Acquired factor XI inhibitors rarely occur spontaneously.
Reference Values
Only orderable as part of a profile. For more information see 11INE / Factor XI Inhibitor Evaluation, Plasma
An interpretive report will be provided.
Interpretation
When testing is complete, if factor activity results fall within clinically normal ranges, an interpretive comment will be provided noting that inhibitor testing was not indicated and, therefore, not performed. If factor activity indicates the performance of inhibitor screen testing, an interpretive comment will be provided noting the presence or absence of a factor XI inhibitor.
Cautions
Occasionally, a potent lupus-like anticoagulant may cause false-positive testing for a specific factor inhibitor (eg, factor VIII or IX).
Clinical Reference
1. Hoffman R, Benz Jr EJ, Silberstein LE, et al, eds: Hematology: Basic Principles and Practice. 7th ed. Elsevier; 2018
2. Kasper CK. Treatment of factor VIII inhibitors. Prog Hemost Thromb 1989;9:57-86
3. Kottke-Marchant K, ed. Laboratory Hematology Practice Wiley Blackwell Publishing; 2012
Method Description
If the factor XI activity level is normal or elevated, a computer-generated interpretive comment indicating inhibitor testing was not indicated and was not performed will be provided.
Day(s) Performed
Monday through Friday
Report Available
3 to 5 daysSpecimen Retention Time
7 daysPerforming Laboratory
Mayo Clinic Laboratories in Rochester
Test Classification
Not ApplicableCPT Code Information
85390
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| 11INT | FXI Inhib Profile Tech Interp | 69049-5 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 11INT | FXI Inhib Profile Tech Interp | 69049-5 |