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HelpMayo Test ID 8AINH Factor VIII Inhibitor Profile, Professional Interpretation
Specimen Required
Useful For
Interpretation for the detection of the presence and titer of a specific factor inhibitor directed against coagulation factor VIII
Method Name
Only orderable as a reflex. For more information see 8INHE / Factor VIII Inhibitor Evaluation, Plasma.
Medical Interpretation
Reporting Name
FVIII Inhib Profile Prof InterpSpecimen Type
Plasma Na CitSpecimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Plasma Na Cit | Frozen | 14 days |
Clinical Information
Factor VIII (FVIII) inhibitors are IgG antibodies directed against coagulation FVIII that typically result in development of potentially life-threatening hemorrhage. These antibodies may develop in 1 of 4 different patient populations:
-Patients with congenital FVIII deficiency (hemophilia A) in response to therapeutic infusions of factor VIII concentrate
-Older nonhemophiliac adult patients (not previously factor VIII deficient)
-Women in postpartum period
-Patients with other autoimmune illnesses
Reference Values
Only orderable as a reflex. For more information see 8INHE / Factor VIII Inhibitor Evaluation, Plasma.
An interpretive report will be provided.
Interpretation
When no significant abnormalities are detected, a simple descriptive interpretation is provided. When abnormal results are detected, a detailed interpretation is given, including an overview of the results and of their significance, a correlation to available clinical information, and elements of differential diagnosis.
Cautions
No significant cautionary statements
Clinical Reference
1. Kasper CK. Treatment of factor VIII inhibitors. Prog Hemost Thromb. 1989;9:57-86
2. Peerschke EI, Castellone DD, Ledford-Kraemer M, et al. Laboratory assessment of FVIII inhibitor titer. Am J Clin Pathol. 2009;131(4):552-558
3. Pruthi RK, Nichols WL. Autoimmune factor VIII inhibitors. Curr Opin Hematol. 1999;6(5):314-322
4. Kottke-Marchant K, ed. Laboratory Hematology Practice. Wiley Blackwell Publishing; 2012
5. Hoffman R, Benz Jr EJ, Silberstein LE, et al, eds. Hematology: Basic Principles and Practice. 7th ed. Elsevier; 2018
Method Description
A coagulation expert (clinician or hematopathologist) reviews the laboratory data, and an interpretive report is issued.
Day(s) Performed
Monday through Friday
Report Available
3 to 5 daysPerforming Laboratory
Mayo Clinic Laboratories in Rochester
Test Classification
Not ApplicableCPT Code Information
85390-26
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| 8AINH | FVIII Inhib Profile Prof Interp | 69049-5 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 607486 | Reviewed by | 18771-6 |
| 607442 | FVIII Inhib Profile Prof Interp | 69049-5 |