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HelpMayo Test ID ALUPI Lupus Anticoagulant Profile, Technical Interpretation
Specimen Required
Only orderable as part of a profile. For more information see ALUPP / Lupus Anticoagulant Profile, Plasma.
Useful For
Technical interpretation of testing to confirm or exclude the presence of lupus anticoagulant (LAC)
Distinguishing LAC from specific coagulation factor inhibitors and nonspecific inhibitors
Investigating a prolonged activated thromboplastin time, especially when combined with other coagulation studies
This test is not useful for the detection of antiphospholipid antibodies that do not affect coagulation tests. We recommend separate testing for serum phospholipid (cardiolipin) antibodies.
Method Name
Only orderable as part of a profile. For more information see ALUPP / Lupus Anticoagulant Profile, Plasma.
Technical Interpretation
Reporting Name
Lupus Anticoagulant Tech InterpSpecimen Type
Plasma Na CitSpecimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Plasma Na Cit | Frozen | 14 days |
Reject Due To
| Gross hemolysis | Reject |
| Gross lipemia | Reject |
| Gross icterus | Reject |
Clinical Information
Lupus anticoagulant (LAC) is an antibody to negatively charged phospholipid that interferes with phospholipid-dependent coagulation tests.
LAC is found in, but not limited to, patients with systemic lupus erythematosus; LAC is associated with other autoimmune disorders and collagen vascular disease, occurs in response to medications or certain infections (eg, respiratory tract infections in children), and in individuals with no obvious underlying disease.
LAC has been associated with arterial and venous thrombosis and fetal loss. Individuals with thrombocytopenia or factor II deficiency associated with LAC may be at risk for bleeding.
Reference Values
Only orderable as part of a profile. For more information see ALUPP / Lupus Anticoagulant Profile, Plasma.
An interpretive report will be provided.
Interpretation
When testing is complete, if the prothrombin time, activated partial thromboplastin time, and dilute Russell's viper venom time fall within clinically normal ranges, an interpretive comment will be provided noting no evidence of a lupus anticoagulant.
Cautions
Patient should not be receiving warfarin or heparin. If the patient is currently on warfarin or heparin, this should be noted, treatment with heparin causes false-positive results of in vitro coagulation testing for lupus anticoagulant. Coumadin treatment may impair ability to detect the more subtle varieties of lupus-like anticoagulants.
Clinical Reference
1. Arnout J, Vermylen J. Current status and implications of autoimmune antiphospholipid antibodies in relation to thrombotic disease. J Thromb Haemost 2003;1(5):931-942
2. Levin JS, Branch DW, Rauch J. The antiphospholipid syndrome. New Engl J Med 2002;346(10):752-763
3. Proven A, Bartlett RP, Moder KG, et al. Clinical importance of positive tests for lupus anticoagulant and anticardiolipin antibodies. Mayo Clin Proc 2004;79(4):467-475
Method Description
If the prothrombin time, activated partial thromboplastin time, and dilute Russell viper venom time are normal, a computer-generated interpretive comment will be provided indicating no evidence of a lupus anticoagulant.
Day(s) Performed
Monday through Friday
Report Available
3 to 5 daysSpecimen Retention Time
7 daysPerforming Laboratory
Mayo Clinic Laboratories in Rochester
Test Classification
Not ApplicableCPT Code Information
85390
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| ALUPI | Lupus Anticoagulant Tech Interp | 75882-1 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| ALUPI | Lupus Anticoagulant Tech Interp | 75882-1 |