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HelpMayo Test ID ALUPO Lupus Anticoagulant Profile Interpretation
Specimen Required
Useful For
Interpretation of testing performed as part of a profile to confirme or exclude the presence of lupus anticoagulant (LAC), distinguishing LAC from specific coagulation factor inhibitors and nonspecific inhibitors
Interpretation of testing performed as part of a profile to investigatie a prolonged activated thromboplastin time, especially when combined with other coagulation studies
This test is not useful for the detection of antiphospholipid antibodies that do not affect coagulation tests. We recommend separate testing for serum phospholipid (cardiolipin) antibodies.
Method Name
Only orderable as a reflex. For more information see ALUPP / Lupus Anticoagulant Profile, Plasma.
Medical Interpretation
Reporting Name
Lupus Anticoagulant InterpSpecimen Type
Plasma Na CitSpecimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Plasma Na Cit | Frozen | 14 days |
Reject Due To
| Gross hemolysis | Reject |
| Gross lipemia | Reject |
| Gross icterus | Reject |
Clinical Information
Lupus anticoagulant (LAC) is an antibody to negatively charged phospholipid that interferes with phospholipid-dependent coagulation tests.
LAC is found in, but not limited to, patients with systemic lupus erythematosus; LAC is associated with other autoimmune disorders and collagen vascular disease and occurs in response to medications or certain infections (eg, respiratory tract infections in children) and in individuals with no obvious underlying disease.
LAC has been associated with arterial and venous thrombosis and fetal loss. Individuals with thrombocytopenia or factor II deficiency associated with LAC may be at risk for bleeding.
Reference Values
Only orderable as a reflex. For more information see ALUPP / Lupus Anticoagulant Profile, Plasma.
An interpretive report will be provided.
Interpretation
An interpretive report will be provided when testing is complete, noting a presence or absence of a lupus anticoagulant.
Clinical Reference
1. Arnout J, Vermylen J. Current status and implications of autoimmune antiphospholipid antibodies in relation to thrombotic disease. J Thromb Haemost. 2003;1(5):931-942
2. Levin JS, Branch DW, Rauch J.: The antiphospholipid syndrome. New Engl J Med. 2002;346(10):752-763
3. Proven A, Bartlett RP, Moder KG, et al. Clinical importance of positive tests for lupus anticoagulant and anticardiolipin antibodies. Mayo Clin Proc. 2004;79(4):467-475
4. Favaloro EJ, Lippi G, eds. Hemostasis and Thrombosis: Methods and Protocols. Humana Press; 2017
Method Description
A coagulation expert (clinician or hematopathologist) reviews the laboratory data and an interpretive report is issued.
Day(s) Performed
Monday through Friday
Report Available
3 to 5 daysSpecimen Retention Time
7 daysPerforming Laboratory
Mayo Clinic Laboratories in Rochester
CPT Code Information
85390-26 Special Coagulation Interpretation
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| ALUPO | Lupus Anticoagulant Interp | 75882-1 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 603185 | Reviewed by | 18771-6 |
| 603465 | Lupus Anticoagulant Interp | 75882-1 |