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HelpMayo Test ID CSU Chyluria Screen, Random, Urine
Necessary Information
Indicate patient's age and sex.
Specimen Required
Patient Preparation: Before specimen collection, the patient should not ingest foods or beverages rich in vitamin C or take vitamin C supplements.
Supplies: Urine Container, 60 mL (T313)
Container/Tube: Plastic, 60-mL urine bottle
Specimen Volume: 15 mL
Collection Instructions: Collect a first-morning, random urine collection.
Useful For
Aiding in the diagnosis of chyluria (galacturia)
Method Name
Enzymatic Colorimetric/Electrophoresis/Spectrophotometry (SP)
Reporting Name
Chyluria Screen, Random, USpecimen Type
UrineSpecimen Minimum Volume
15 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Urine | Frozen (preferred) | 10 days | |
| Refrigerated | 10 days | ||
| Ambient | 4 hours |
Reject Due To
All specimens will be evaluated at Mayo Clinic Laboratories for test suitability.Clinical Information
Chyluria is a medical condition in which chyle is present in the urine. Chyle is a milky substance composed of lymphatic fluid and chylomicrons formed in the small intestine during the digestion of fatty foods. Chyluria is most prevalent in tropical areas where it is caused by parasitic (Wuchereria bancrofti) infections spread by mosquitoes. Parasitic chyluria is so rare as to be nonexistent in the continental United States. Nonparasitic chyluria causes include traumatic lesions, tumors, lymphangioma, pregnancy, and granulomatous infections.
Reference Values
No lipoproteins present
Interpretation
This assay provides information regarding the fat content in urine fluid. Urinary cholesterol and triglyceride values are normally less than 10 mg/dL. High triglyceride levels in urine may indicate chyluria.
Cautions
Ascorbic acid (vitamin C) interferes with the cholesterol determination and, to a lesser degree, the triglyceride concentration. Ascorbic acid falsely decreases the cholesterol and triglyceride results.
Result can be falsely decreased in patients with elevated levels of N-acetyl-p-benzoquinone imine (NAPQI)-a metabolite of acetaminophen, N-acetylcysteine, and metamizole.
Clinical Reference
1. Diamond E, Schapira HE. Chyluria-a review of the literature. Urology. 1985;26(5):427-431
2. Mendu DR, Sternlicht H, Ramanathan LV, et al. Two cases of spontaneous remission of non-parasitic chyluria. Clin Biochem. 2017;50(15):886-888. doi:10.1016/j.clinbiochem.2017.05.002
Method Description
This test involves 2 steps, centrifugation and lipoprotein electrophoresis, to detect the visual presence of chylomicrons. The specimen also is analyzed for cholesterol and triglycerides using an enzymatic colorimetric method. The results of the cholesterol, triglycerides, and lipoprotein electrophoresis are used together to determine whether the sample is chyluria.(Unpublished Mayo information)
Day(s) Performed
Monday through Friday
Report Available
2 to 5 daysSpecimen Retention Time
6 daysPerforming Laboratory
Mayo Clinic Laboratories in Rochester
Test Classification
This test has been modified from the manufacturer's instructions. Its performance characteristics were determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the US Food and Drug Administration.CPT Code Information
82664-Electrophoretic technique, not elsewhere specified (Chylomicrons and lipoproteins)
84311-Spectrophotometry, analyte not specified (Cholesterol)
84478-Triglycerides
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| CSU | Chyluria Screen, Random, U | 95808-2 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| CHOLU | Cholesterol, Random, U | 14444-4 |
| TRIGU | Triglycerides, Random, U | 14450-1 |
| CMTCS | Interpretive Comment | 95807-4 |