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HelpMayo Test ID HAEV0 Hemolytic Anemia Summary Interpretation
Useful For
Incorporating and summarizing subsequent results into an overall evaluation if 1 or more molecular tests are reflexed on HAEV1 / Hemolytic Anemia Evaluation, Blood.
Testing Algorithm
This test is an additional consultative interpretation that summarizes all testing as well as any pertinent clinical information, and will be provided after all tests are completed to incorporate subsequent results into an overall evaluation if 1 or more of the following molecular tests are reflexed on the HAEV1 / Hemolytic Anemia Evaluation, Blood:
-ATHAL / Alpha-Globin Gene Analysis, Varies
-WASQR / Alpha-Globin Gene Sequencing, Blood
-WBSQR / Beta-Globin Gene Sequencing, Blood
-WBDDR / Beta-Globin Cluster Locus Deletion/Duplication, Blood
-WGSQR / Gamma-Globin Full Gene Sequencing, Varies
This summary is in addition to interpretations that may be provided for individual components.
Method Name
Only orderable as a reflex. For more information see HAEV1 / Hemolytic Anemia Evaluation, Blood.
Medical Interpretation
Reporting Name
Hemolytic Anemia Summary InterpSpecimen Type
Whole Blood EDTASpecimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Whole Blood EDTA | Refrigerated | ||
Clinical Information
The evaluation of patients with hemolytic anemia can be very complex and involves incorporation of not only testing, but integration of clinical and peripheral blood findings. Nonimmune hemolytic anemia can be due to many causes, including abnormalities in the hemoglobin molecule, red blood cell (RBC) membrane/cytoskeleton, or RBC enzyme cascade. If the evaluation of nonimmune hemolytic anemia utilizes the reflex molecular tests, a summary interpretation will be added to summarize the genetic, protein, peripheral blood, and clinical findings (if provided) will be added. This is beneficial to the ordering provider.
Reference Values
Only orderable as a reflex. For more information see HAEV1 / Hemolytic Anemia Evaluation, Blood.
An interpretation report will be provided.
Interpretation
An interpretive report will be provided that summarizes all testing as well as any pertinent clinical information.
Cautions
No significant cautionary statements
Clinical Reference
1. Steiner LA, Gallagher PG. Erythrocyte disorders in the perinatal period. Semin Perinatol. 2007;31(4):254-261
2. Beutler E. Glucose-6-phosphate dehydrogenase deficiency and other enzyme abnormalities. In: Beutler E, Lichtman MA, Collar BS, Kipps TJ, eds. Hematology. 5th ed. McGraw-Hill Book Company; 1995:564-581
3. Hoyer JD, Hoffman DR. The thalassemia and hemoglobinopathy syndromes. In: McClatchey KD, ed. Clinical Laboratory Medicine. 2nd ed. Lippincott, Williams and Wilkin; 2002:866-895
4. King MJ, Garcon L, Hoyer JD, et al. International Council for Standardization in Haematology: ICSH guidelines for the laboratory diagnosis of nonimmune hereditary red cell membrane disorders. Int J Lab Hematol. 2015;37(3):304-325
5. Lux SE. Anatomy of the red cell membrane skeleton: unanswered questions. Blood. 2016;127(2):187-199 doi:10.1182/blood-2014-12-512772
6. Gallagher PG. Abnormalities of the erythrocyte membrane. Pediatr Clin North Am. 2013;60(6):1349-1362
7. Bianchi P, Fermo E, Vercellati C, et al. Diagnostic power of laboratory tests for hereditary spherocytosis: a comparison study in 150 patients grouped according to molecular and clinical characteristics. Haematologica. 2012;97(4):516-523
8. Glader B. Hereditary hemolytic anemias due to red blood cell enzyme disorders. In: Greer JP, Arber DA, Glader B, et al, eds. Wintrobe's Clinical Hematology. 13th ed. Wolters Kluwer/Lippincott, Williams and Wilkins; 2014:728
9. Kipp BR, Roellinger SE, Lundquist PA, Highsmith WE, Dawson DB. Development and clinical implementation of a combination deletion PCR and multiplex ligation-dependent probe amplification assay for detecting deletions involving the human alpha-globin gene cluster. J Mol Diagn. 2011;13(5):549-557 doi: 10.1016/j.jmoldx.2011.04.001
10. Harteveld CL, Higgs DR. Alpha-thalassemia. Orphanet J Rare Dis. 2010;5:13
11. Thein SL. The molecular basis of beta-thalassemia. Cold Spring Harb Persepct Med. 2013;1;3(5):a011700
12. Hein MS, Oliveira JL, Swanson KC, et al. Large deletions involving the beta globin gene complex: genotype-phenotype correlation of 119 cases. Blood. 2015;126:3374
13. Gallagher PG. Diagnosis and management of rare congenital nonimmune hemolytic disease. Hematology Am Soc Hematol Educ Program. 2015;2015:392-399
14. Koralkova P, van Solinge WW, van Wijk R. Rare hereditary red blood cell enzymopathies associated with hemolytic anemia - pathophysiology, clinical aspects, and laboratory diagnosis. Int J Lab Hematol. 2014;36(3):388-397
Method Description
A hematopathologist evaluates all of the testing performed and a summary interpretive report is added.
Performing Laboratory
Mayo Clinic Laboratories in Rochester
Test Classification
Not ApplicableLOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| HAEV0 | Hemolytic Anemia Summary Interp | In Process |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 608090 | Hemolytic Anemia Summary Interp | 14869-2 |
| 608115 | Reviewed By | 18771-6 |
Day(s) Performed
Monday through Friday