Home
HelpMayo Test ID HBEL0 Hemoglobin Electrophoresis Summary Interpretation
Useful For
Incorporating and summarizing results into an overall evaluation with consultative interpretation on the HBEL1 / Hemoglobin Electrophoresis Evaluation, Blood
Testing Algorithm
This test is an additional consultative interpretation that summarizes all testing as well as any pertinent clinical information available for review, and will be provided after all reflexed tests have been completed. If performed, subsequent molecular results will also be incorporated into the overall evaluation. One or more of the following molecular tests may be reflexed on the HBEL1 / Hemoglobin Electrophoresis Evaluation, Blood:
-ATHAL / Alpha-Globin Gene Analysis, Varies
-WASQR / Alpha-Globin Gene Sequencing, Blood
-WBSQR / Beta-Globin Gene Sequencing, Blood
-WBDDR / Beta-Globin Cluster Locus Deletion/Duplication, Blood
-WGSQR / Gamma-Globin Full Gene Sequencing, Varies
This summary is in addition to interpretations that may be provided for each component.
Method Name
Only orderable as a reflex. For more information see HBEL1 / Hemoglobin Electrophoresis Evaluation, Blood.
Medical Interpretation.
Reporting Name
Hb Electrophoresis Summary InterpSpecimen Type
Whole Blood EDTASpecimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Whole Blood EDTA | Refrigerated | ||
Clinical Information
The evaluation of hemoglobin disorders can be very complex. This can involve abnormalities in the alpha, beta, delta, or gamma chains. Molecular testing is performed to fully evaluate complex situations. A summary interpretation that incorporates all of the testing performed is beneficial to the ordering physician.
Reference Values
Only orderable as a reflex. For more information see HBEL1 / Hemoglobin Electrophoresis Evaluation, Blood.
An interpretive report will be provided.
Interpretation
An interpretive report will be provided that summarizes all testing as well as any pertinent clinical information.
Cautions
No significant cautionary statements.
Clinical Reference
1. Hoyer JD, Hoffman DR. The thalassemia and hemoglobinopathy syndromes. In: McClatchey KD, ed. Clinical Laboratory Medicine. 2nd ed. Lippincott Williams and Wilkins; 2002:866-895
2. Harteveld CL, Higgs DR. Alpha-thalassemia. Orphanet J Rare Dis. 2010;5:13
3. Thein SL. The molecular basis of beta-thalassemia. Cold Spring Harb Perspect Med. 2013;3(5):a011700
4. Crowley MA, Mollan TL, Abdulmalik OY, et al. A hemoglobin variant associated with neonatal cyanosis and anemia. N Engl J Med. 2011;364(19):1837-1843
5. Kipp BR, Roellinger SE, Lundquist PA, Highsmith WE, Dawson DB. Development and clinical implementation of a combination deletion PCR and multiplex ligation-dependent probe amplification assay for detecting deletions involving the human alpha-globin gene cluster. J Mol Diagn. 2011;13(5):549-557. doi:10.1016/j.jmoldx.2011.04.001
6. Hein MS, Oliveira JL, Swanson KC, Lundquist PA. Large deletions involving the beta globin gene complex: genotype-phenotype correlation of 119 cases. Blood. 2015;126(23):3374. doi:10.1182/blood.V126.23.3374.3374
Method Description
A hematopathologist evaluates all of the testing performed and a summary interpretive report is added.
Performing Laboratory
Mayo Clinic Laboratories in Rochester
Test Classification
Not ApplicableCPT Code Information
83020-26
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| HBEL0 | Hb Electrophoresis Summary Interp | In Process |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 608091 | Hb Electrophoresis Summary Interp | 13514-5 |
| 608117 | Reviewed By | 18771-6 |
Day(s) Performed
Monday through Friday