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Mayo Test ID PBOU Lead Occupational Exposure, Random, Urine


Specimen Required


Only orderable as part of profile. For more information see:

-PBUOE / Lead Occupational Exposure, Random, Urine

-HMUOE / Heavy Metal Occupational Exposure, with Reflex, Random, Urine


Useful For

Detecting clinically significant lead exposure due to occupational exposure in random urine specimens

 

This test is not a substitute for blood lead screening.

Method Name

Only orderable as part of profile. For more information see:

-PBUOE / Lead Occupational Exposure, Random, Urine

-HMUOE / Heavy Metal Occupational Exposure, with Reflex, Random, Urine

 

Triple-Quadrupole Inductively Coupled Plasma Mass Spectrometry (ICP-MS/MS)

Reporting Name

Lead Occupational Exposure

Specimen Type

Urine

Specimen Minimum Volume

1.5 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Urine Refrigerated (preferred) 28 days
  Ambient  28 days
  Frozen  28 days

Reject Due To

  All specimens will be evaluated at Mayo Clinic Laboratories for test suitability.

Clinical Information

Lead toxicity primarily affects the gastrointestinal, neurologic, and hematopoietic systems. Increased urine lead concentration per gram of creatinine indicates significant lead exposure. Measurement of urine lead concentration per gram of creatinine before and after chelation therapy has been used as an indicator of significant lead exposure. An increase in lead concentration per gram of creatinine in the post-chelation specimen of up to 6 times the concentration in the pre-chelation specimen is normal.

 

Blood lead measurement is the best test for clinical correlation of toxicity. For more information, see PBDV / Lead, Venous, with Demographics, Blood.

Reference Values

Only orderable as part of profile. For more information see:

-PBUOE / Lead Occupational Exposure, Random, Urine

-HMUOE / Heavy Metal Occupational Exposure, with Reflex, Random, Urine

 

Biological Exposure Index (BEI): <150 mcg/g creatinine

Interpretation

Urinary excretion of less than 4 mcg/g creatinine is not associated with any significant lead exposure.

 

Urinary excretion of more than 4 mcg/g creatinine is usually associated with pallor, anemia, and other evidence of lead toxicity.

Cautions

No significant cautionary statements

Clinical Reference

1. Kosnett MJ, Wedeen RP, Rotherberg SJ, et al. Recommendations for medical management of adult lead exposure. Environ Health Perspect. 2007;115(3):463-471

2. de Burbane C, Buchet JP, Leroyer A, et al. Renal and neurologic effects of cadmium, lead, mercury, and arsenic in children: evidence of early effects and multiple interactions at environmental exposure levels. Environ Health Perspect. 2006;114(4):584-590

3. Strathmann FG, Blum LM. Toxic elements. In: Rifai N, Chiu RWK, Young I, Burnham CD, Wittwer CT, eds. Tietz Textbook of Laboratory Medicine. 7th ed. Elsevier; 2023:chap 44

4. Hauptman M, Bruccoleri R, Woolf AD. An update on childhood lead poisoning. Clin Pediatr Emerg Med. 2017;18(3):181-192. doi:10.1016/j.cpem.2017.07.010

Method Description

The metal of interest is analyzed by triple-quadrupole inductively coupled plasma mass spectrometry.(Unpublished Mayo method)

Specimen Retention Time

14 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

LOINC Code Information

Test ID Test Order Name Order LOINC Value
PBOU Lead Occupational Exposure 13466-8

 

Result ID Test Result Name Result LOINC Value
608894 Lead Occupational Exposure 13466-8

Day(s) Performed

Monday through Friday

Report Available

2 to 4 days

CPT Code Information

83655